Adelmidrol (1675-66-7)

Adelmidrol Sawọn ilana

Kini Adelmidrol (1675-66-7)?

Adelmidrol is the semisynthetic diethanolamide derivative of azelaic acid, and has a symmetrical chemical structure. It classed as an amide, and is similar to palmitoylethanolamide, the parent molecule in the ALIAmide class of drugs. ALIAmides are group of ọra-wara derivatives with cannabimimetic properties which have anti-inflammatory and analgesic effects and are thought to act by reducing mast cell activation. Adelmidrol is an anti-inflammatory ethanolamide derivative of azelaic acid.

Adelmidrol (1675-66-7) anfani

Adelmidrol jẹ itọsẹ sintetiki ti azelaic acid, dicarboxylic acid ti o kunju ti o nwaye nipa ti ara, ti o wa ni diẹ ninu awọn irugbin odidi ati ni awọn iye to wa ninu ara eniyan. Kemikali, ademidrol jẹ N, N-bis (2-hydroxyethyl) ti kii ṣe anediamide ati pe o jẹ ẹya amphiphilic tabi apapọ amphipathic, ti o ni awọn ohun-ini hydrophilic mejeeji ati hydrophobic, ti o ṣe ojurere solubility mejeeji ni olomi ati media Organic. Adelmidrol jẹ ti idile aliamide, ẹgbẹ kan ti awọn itọsẹ acid ọra pẹlu awọn ohun-ini cannabimimetic, ni anfani lati ṣakoso hyperreactivity sẹẹli mast (MC) ni ọpọlọpọ awọn pathophysiological ati awọn ipo iṣan. Ọna NF-κB Pro-inflammatory ti dinku ni pataki nipasẹ itọju pẹlu adelmidrol. Ipa egboogi-iredodo ti adelmidrol farahan lati ni ibatan lori imuṣiṣẹ PPAR-gamma. Adelmidrol jẹ doko ni oke fun awọn rudurudu awọ iredodo eniyan ati pe o ni anfani lati ṣe iyipada esi iredodo ni keratinocytes eniyan. Apapọ hyaluronic acid ati adelmidrol ṣe ilọsiwaju awọn ami ti osteoarthritis ti o fa nipasẹ monosodium iodoacetate.

Adelmidrol (1675-66-7) ohun elo?

Adelmidrol jẹ itọsẹ semisynthetic ti azelaic acid ati afọwọṣe ti agbo anti-iredodo palmitoylethanolamide (PEA), aliamide ati ọmọ ẹgbẹ ti idile ti fatty acid amide ifihan awọn ohun elo pẹlu awọn ohun-ini cannabimimetic. Awọn ipa-egbogi-iredodo ati awọn ipa antinociceptive ti aliamides PEA ati adelmidrol ni a ti ṣe afihan ni ọpọlọpọ awọn ẹkọ-iṣaaju iṣaaju, mejeeji ni vitro ati ni vivo. Awọn iṣe wọn ni a ro pe o jẹ nitori, o kere ju ni apakan, si agbara wọn lati ṣe atunṣe-ṣiṣẹsẹhin sẹẹli mast ati itusilẹ olulaja sẹẹli mast ni awọn ipo iṣan-ara ati awọn arun aisan.

Adelmidrol lulú fun sale(Nibo lati Ra Adelmidrol lulú ni olopobobo)

Ile-iṣẹ wa gbadun awọn ibatan igba pipẹ pẹlu awọn alabara wa nitori a dojukọ alabara iṣẹ ati pese awọn ọja nla. Ti o ba nifẹ si ọja wa, a ni irọrun pẹlu isọdi ti awọn ibere lati ba iwulo rẹ pato ati akoko itọsọna iyara wa lori awọn iṣeduro awọn iṣeduro pe iwọ yoo ni itọwo nla ọja wa ni akoko. A tun ṣe idojukọ awọn iṣẹ ti a fi kun iye. A wa fun awọn ibeere iṣẹ ati alaye lati ṣe atilẹyin iṣowo rẹ.

We are an professional Adelmidrol powder supplier for several years, we supply awọn ọja pẹlu idiyele ifigagbaga, ati pe ọja wa jẹ didara ti o ga julọ ati pe o ṣe idanwo ti o muna, idanwo ominira lati rii daju pe o jẹ ailewu fun lilo ni ayika agbaye.

jo

1. Cerrato, Santiago; Brazil, Pilar; della Valle, Maria Federica; Miolo, Alda; Puigdemont, Anna (2012). "Ipa idalọwọduro ti Adelmidrol ti agbegbe lori antigen-induced skin whal ati ihuwasi sẹẹli mast ni awoṣe ireke ti dermatitis aleji”. BMC Veterinary Iwadi. 8 (1): 230. doi: 10.1186 / 1746-6148-8-230. PMC 3540011. PMID 23181761.
2. Cordaro, M; Impellizzeri, D; Gugliandolo, E; Siracusa, R; Crupi, R; Esposito, E; Cuzzocrea, S (2016). "Adelmidrol, Palmitoylethanolamide Analogue, gẹgẹbi Itọju Ẹjẹ Titun Titun fun Itọju Arun Ifun Ifun". Molecular Pharmacology. 90 (5): 549–561. doi:10.1124/mol.116.105668. PMID 27625036.
3. Abramo, F; Salluzzi, D; Leotta, R; Auxili, S; Nólì, C; Miolo, A; Mantis, P; Lloyd, D. H (2008). “Mofometry sẹẹli mast ati densitometry ni awọn ọgbẹ awọ idanwo ti a tọju pẹlu jeli ti o ni adelmidrol: Iwadii iṣakoso ibibo”. Awọn ọgbẹ : Akopọ ti Iwadi Ile-iwosan ati Iṣeṣe. 20 (6): 149–57. PMID 25942520.

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